The main goal of the project is the development of compact and low cost CMOS-MEMS platforms for bio-sensing applications based on the adoption of microelectromechanical resonators (MEMS) as the sensing element integrated monolithically with CMOS circuits. This approach would attain high-sensitive CMOS-MEMS oscillator circuits enabling the sensor continuous tracking through the quasi-digital output signal provided. Based on our previous experience we are aimed to exploit commercial and mature submicrometer-scale CMOS technologies to develop such devices providing both high-performance and low cost. The proposal envisages the development of CMOS-MEMS sensor devices based on two operation principles: i) thermal biosensing, or biocalorimeters, based on the use of high-sensitivity MEMS resonators with temperature, and ii) gravimetric biosensing of volatile organic compounds (VOC) using extreme mass sensitive MEMS resonators. Although having dissimilar operating principles their implementation and development through resonant CMOS-MEMS oscillators is technologically compatible. In both cases the sensing element is a MEMS resonator with electrostatic actuation and capacitive readout that will allow its full integration within standard CMOS ICs. We plan to develop various prototypes for each approach considering at least two submicrometer CMOS technological nodes with the goal of surpassing the state-of-the-art sensitivities. Moreover, the planned multidisciplinary collaborations are aimed at providing a final application, as there will be efforts to integrate the microfluidic channels together with the thermal sensors that could provide sensitivity at the cellular level. Similarly a newly developed specific coating technique for the mass sensors targeting specifically the CMOS metal layers will be experienced to measurement VOC acetone concentration as an indirect determination for the glucose levels in plasma.